Core Nutritionals| Ascension Elite Pre-Workout (Doug Miller'S Pre)

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Ascension Pre Workout by Core Nutritionals is their most loaded, elite daily driver to date. Armed with a deep understanding of the nuances that contribute to a successful workout, Core set out to create the ultimate pre workout experience. ASCENSION is just that! This pre workout checks all the boxes when it comes to pump, power, endurance, hydration, focus, and energy. This pre workout is Doug Millers (Cores' Owner) signature pre workout. This is Dougs personal message to the world on his pre workout:

"Over the last 25+ years, I has produced, tested, and tried some of the most well-known and effective preworkout supplements. Being a world champion natural bodybuilder and entrepreneur in the supplement industry, I have worked tirelessly on revolutionizing the industry. Also, as a scientist and consumer, I have been committed to making sure Core Nutritionals® only formulates high-end, efficaciously dosed products for almost 20 years! Our CRUSH IT® Lifestyle demands this!"

Ascension Pre Workout Highlights

  • Cores' Most Loaded Pre Workout
  • Elite Daily Driver Pre Workout
  • 5g Creatine Monohydrate
  • 401mg Active Caffeine from 2 Sources

Ascension Pre Workout Ingredients

  • L-Citrulline

Citrulline is a non-essential, non-protein amino acid that forms during the urea cycle and forms ornithine when combined with carbon dioxide. Citrulline is also a critical source of endogenous (natural) arginine, as it is rapidly and efficiently converted to arginine in the vascular endothelium and other tissues.

  • Beta Alanine

Carnosine, a critical compound for muscle function, has long intrigued researchers due to its essential role in buffering pH levels in muscle cells, particularly during intense exercise. However, efforts to increase intramuscular carnosine levels via direct supplementation faced challenges due to rapid degradation in the body. The introduction of beta-alanine, a precursor to carnosine, revolutionized this approach. Beta-alanine has proven to be highly effective in significantly increasing intramuscular carnosine concentrations, thereby unlocking carnosine's beneficial effects on muscle performance. Moreover, beta-alanine itself exhibits physiological benefits beyond its role as a carnosine precursor. By synthesizing carnosine from the precursors L-histidine and l-alanine, carnosine acts as a chemical buffer in muscle cells, crucial for sustained performance during intense exercise.

  • Creatine Monohydrate

Creatine, often hailed as the "grandfather" of dietary supplements, stands alongside caffeine as one of the most extensively researched compounds in the field. Renowned as the premier ergogenic aid, the wealth of data on creatine illustrates its multifaceted benefits. Primarily, it promotes vasodilation, facilitates nutrient mobilization, enhances nitrogen retention, and augments protein synthesis post-workout. Its prowess lies in its ability to dose-dependently elevate contractile force through ATP provision, essentially bolstering strength.

  • Arginine Nitrate (as NO3-T®)

Nitric oxide (NO) is involved in many vascular and cellular functions as a signaling molecule for cellular respiration, vasodilation, and angiogenesis. NO is produced through both endogenous and exogenous pathways through dietary nitrate ingestion. Nitrates are converted to nitrite, which is then converted to nitric oxide. Found naturally in many foods such as leafy greens and beets, NO has a long history of scientific literature to back its potential effects as an ergogenic aid and other health-promoting effects.

  • Hydroprime® (65% Glycerol Powder)

Glycerol is a fascinating and highly useful compound that has achieved a somewhat cult status in the fitness community – while both peer-reviewed research and anecdotal reports centered on the endurance functions of glycerol are plentiful, its bodybuilding applications are not as widely lauded. Those who do use glycerol, however, are persistent in their belief that it provides some of the most noticeable, and effective, engorging (“pump”) effects possible.

  • L-Tyrosine

Tyrosine is amongst a class of amino acids known as ‘non-essential’ amino acids, so called because the body can produce them endogenously, and it is therefore not essential to consume dietary tyrosine. That said, tyrosine is also what is known as a conditionally essential amino acid; conditionally essential because, along with glucose and ammonia, the synthesis of tyrosine additionally requires adequate levels of phenylalanine. Once synthesized, tyrosine is one of the most critical amino acids, given its prominent role as a substrate in the synthesis of the catecholamines dopamine, norepinephrine, and epinephrine, in addition to both T3 (triiodothyronine) and T4 (thyroxine) thyroid hormones.

In studies on stress modulation, tyrosine has been demonstrated to reverse stress-induced norepinephrine depletion and the depressant-behavioral effects normally associated with it. In simpler terms, tyrosine may, in certain conditions, dampen the extent to which norepinephrine is removed from the bloodstream during a stress event. In simpler terms still, tyrosine may help to mitigate the sense of depletion and fatigue felt at the end of a workout.

Tyrosine may also play important metabolic functions, mostly related to its role in synthesizing compounds which stimulate the nervous system. While not traditionally considered a sympathomimetic amine, studies which have coadministered tyrosine and stimulants demonstrate a synergistic effect. These studies suggest that tyrosine may potentiate the effects of both endogenous and supplemental norepinephrine and its mimetics (in the case of exogenous use) with respect to lipolysis, thermogenesis, and energy expenditure. Meaning that tyrosine may play a role in assisting norepinephrine to break up triglycerides and increase body heat transiently.

  • L-Taurine

Traditionally referred to as an amino acid due to its chemical structure, taurine is not an amino acid in the sense that leucine, alanine, or glutamine are. Its chemical status aside, taurine is considered one of the body’s most essential chemical compounds, as cardiovascular function, muscle development and function, along with optical and nervous systems in the body depend on its abundance. While data on taurine typically occurs with taurine in supplement combinations (with caffeine and other amino acids), these data nevertheless suggest that dietary supplementation with taurine may have beneficial effects on mental focus and alertness and may assist during times of increased physical exertion.

  • Alpha-GPC 50%

Among the various choline pro-drugs or precursors, Alpha GPC stands out for its significant impact on circulating choline levels. Choline, an essential nutrient, plays a crucial role in numerous metabolic pathways, including DNA regulation, protein function, and metabolism. Notably, choline serves as a precursor for the synthesis of acetylcholine, a critical neurotransmitter involved in various physiological functions, such as muscular contraction and cognitive processes like memory and learning. 

  • VasoDrive-AP®

Vasodrive-AP® is a patented dietary supplement ingredient composed of a precise blend of naturally derived peptides, primarily derived from casein hydrolysate. This ingredient has garnered attention for its potential benefits in enhancing exercise performance through its vasodilatory properties. Vasodrive-AP® works by promoting the release of nitric oxide (NO), a key signaling molecule involved in vasodilation, which leads to the relaxation of blood vessels and increased blood flow to exercising muscles. It does this through several mechanisms of action. First, the increase in the production of endothelial nitric oxide synthase (eNOS) improves arterial flexibility leading to enhanced blood flow.

Second, Vasodrive-AP® can also inhibit the enzyme that leads to the constriction of blood vessels. 

  • Caffeine Anhydrous

Caffeine is one of the most widely consumed, and perhaps one of the most reviewed, psychoactive compounds. Its physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities.

  • Züm-XR® (yields 70% caffeine)

Züm-XR is a patented coating technology that allows the dissolution profile of certain ingredients, primarily caffeine, to have a longer lasting effect in blood serum levels. The release of those ingredients is initiated by an abrasion in the stomach and pH levels between the stomach and the upper gastrointestinal tract. The coating of the microbead technology is a patented timing system with pharmaceutical grade safe polymers. Comparatively speaking, the dissolution profile of Züm-XR caffeine to your typical immediate release caffeine showed that Züm-XR took a far greater amount of time, well over 120 minutes to complete the process of dissolution.

  • Bitter Orange Extract (Citrus aurantium) (30% synephrine)

Bitter orange extract, derived from the fruit of Citrus aurantium, contains a diverse array of bioactive compounds, notably including synephrine, flavonoids, and essential oils. Synephrine, the principal alkaloid in bitter orange extract, exhibits sympathomimetic properties, stimulating the sympathetic nervous system and potentially increasing heart rate, blood pressure, and metabolic rate. 

  • CognatiQ® (Coffea arabica) (Whole Coffee Fruit Extract)

CognatiQ®, an extract derived from the whole fruit Coffea arabica plant, is a clinically proven ingredient shown to stimulate the production of the neuroprotein, Brain-Derived Neurotrophic Factor (BDNF). BDNF has been shown to be crucial in the development, maintenance and repair of neurons and also protect against neurodegeneration. One study comparing other coffee, caffeine, and polyphenol compounds, showed that they were not statistically significant in increasing BDNF % compared to CognatiQ®. The unique polyphenol profile found in CognatiQ® showed to be superior in increasing BDNF concentration.

  • Huperzia serrata Extract (Leaf and Stem) (1% Huperzine A)

Huperzia serrata, a compound found in plant families such as Huperziaceae, Lycopodiaceae, and Selaginella, is native to China. The Lycopodium alkaloid Huperzine-A, present in Core Ascension, was initially extracted from a traditional medicinal preparation in 1984.

  • Pregnenolone

Pregnenolone, or pregn-5-en-3β-ol-20-one, is known as the grandmother hormone due to its precursor role in the endogenous biosynthesis of most steroid hormones. Pregnenolone also has potent intrinsic activity, however, functioning as a neurosteroid. 

  • Rauwolscine (Rauwolfia vomitoria Root Extract) (std. min 90% Alpha Yohimbine)

Alpha Yohimbine, also known as rauwolscine, offers several potential benefits, particularly in the realm of sports performance as well as weight management. As a dietary supplement, it is often touted for its ability to enhance fat loss and promote energy expenditure, making it popular amongst many athletes. Alpha Yohimbine exhibits a mechanism of action that works to antagonize alpha-2 adrenergic receptors, which can lead to increased lipolysis, which is the breakdown of stored fatty acids that can then be used as a fuel source for the body. 

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