CONTRA® is an ultra-premium, highly potent supplement that has been shown to supportnot only increase testosterone, CONTRA® also possesses natural estrogen balancing properties to keep unfavorable estrogen levels at bay and in turn, supporting all of your hard earned gains!† Promotes Hard, Lean, Dry Muscle Gains!†
ASHWAGANDHA (AS KSM-66®):
Ashwagandha is an Ayurvedic adaptogen KSM-66®
10:1 BRASSAIOPSIS GLOMERULATA
3,3'-DIINDOYLYLMETHANE (DIM):
DIM is the main active metabolite of indole-3-carbinol, which is found in many cruciferous vegetables including brussel sprouts, turnips, kale and cabbage. Typical doses of DIM are between 100-300mg daily.
N-COURMAROYLDOPAMINE:
N-coumaroyldopamine is a naturally occurring beta-2 adrenergic receptor agonist that is extracted from Theobroma cacao seems to have an effect in the 20-40mg/d range.
PIPERINE (BLACK PEPPER EXTRACT):
Derived from peppercorns from Piper Nigrum Plants, Bioperine® is a patented extract that is used as a bioavailability enhancer of numerous nutrients via stimulation of the digestive tract. On top of its noted benefits Piperine may also have an indirect function to support thermogenesis.†
NOTE: Contra is meant to be taken for up to 8-12 weeks before cycling off. For maximal benefits, Contra may be stacked with Mania.
SCIENTIFIC REFERENCES:
- Chatterjee, Sandipan, et al. "Comprehensive metabolic fingerprinting of Withania somnifera leaf and root extracts." Phytochemistry10 (2010): 1085-1094.
- Choudhary, Dnyanraj, Sauvik Bhattacharyya, and Kedar Joshi. "Body weight management in adults under chronic stress through treatment with Ashwagandha root extract: a double-blind, randomized, placebo-controlled trial." Journal of evidence-based complementary & alternative medicine1 (2017): 96-106.
- Mahdi, AA et al. Withania somnifera Improves Semen Quality in Stress-Related Male Fertility. Evidence-based Comp Alt Med. 2011
- Wankhede, Sachin, et al. "Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial." Journal of the International Society of Sports Nutrition1 (2015): 43.
- Sodhi, Virender, and Follow Following Unfollow Virender Sodhi. "Ayurvedic Medicine for Sexual Enhancement in Women."
- Chang, Yu-Chen, et al. "Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3, 3′-diindolylmethane, a major in vivo product of dietary indole-3-carbinol." Biochemical pharmacology5 (1999): 825-834.
- Avvakumov GV, Grishkovskaya I, Muller YA, Hammond GL. Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol. J Biol Chem. 2002 Nov 22;277(47):45219-25
- Franks S, MacLusky NJ, Naish SJ, Naftolin F. Actions of catechol oestrogens on concentrations of serum luteinizing hormone in the adult castrated rat: various effects of 4-hydroxyoestradiol and 2-hydroxyoestradiol. J Endocrinol. 1981 May;89(2):289-95.
- Park, Jae B. "N-coumaroyldopamine and N-caffeoyldopamine increase cAMP via beta 2-adrenoceptors in myelocytic U937 cells." The FASEB journal6 (2005): 497-502.
- Lynch, Gordon S., and James G. Ryall. "Role of β-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease." Physiological reviews2 (2008): 729-767.
